DataSet Record GDS4284: Expression Profiles Data Analysis Tools Sample Subsets
Title: Chronic lymphocytic leukemia response to antisense Bcl-2 inhibitor SPC2996: peripheral blood
Cluster AnalysisGDS4284 Cluster Image
Summary: Temporal analysis of peripheral blood from 18 relapsed CLL patients treated with a maximum of 6 doses (0.2-6mg/kg) of SPC2996, an antisense molecule targeting the mRNA of Bcl-2 oncoprotein. Results provide insight into the molecular basis of the immunostimulatory effects of SPC2996 in CLL.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
  • Dürig J, Dührsen U, Klein-Hitpass L, Worm J et al. The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia. Leukemia 2011 Apr;25(4):638-47. PMID: 21358717
Reference Series: GSE27858 Sample count: 56
Value type: count Series published: 2011/05/30