Analysis of cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, and Renal) from the NCI-60 panel. Results provide insight into molecular mechanisms underlying the various cancer types.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citations:
Pfister TD, Reinhold WC, Agama K, Gupta S et al. Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity. Mol Cancer Ther 2009 Jul;8(7):1878-84. PMID: 19584232
Kohn KW, Zeeberg BM, Reinhold WC, Pommier Y. Gene expression correlations in human cancer cell lines define molecular interaction networks for epithelial phenotype. PLoS One 2014;9(6):e99269. PMID: 24940735
Reinhold WC, Sunshine M, Varma S, Doroshow JH et al. Using CellMiner 1.6 for Systems Pharmacology and Genomic Analysis of the NCI-60. Clin Cancer Res 2015 Sep 1;21(17):3841-52. PMID: 26048278
Giovinazzi S, Sirleto P, Aksenova V, Morozov VM et al. Usp7 protects genomic stability by regulating Bub3. Oncotarget 2014 Jun 15;5(11):3728-42. PMID: 25003721
