Gfi1b overexpression in a pro-B Abelson leukemia virus transformed cell line
Summary:
Analysis of Abelson murine leukemia virus (AMuLV) pro-B cell line expressing Gfi1b-estrogen receptor fusion protein. Targeted disruption of transcription factor Gfi1b severly impacts B cell development in vivo. Results provide insight into the role of Gfi1b in normal B cell development.
Schulz D, Vassen L, Chow KT, McWhirter SM et al. Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1. J Exp Med 2012 Jan 16;209(1):187-99. PMID: 22201127
