Iroquois homeobox Irx3 and Irx5 deletion effect on embryonic heart
Summary:
Analysis of E12.5 hearts deficient in both of the Iroquois homeodomain transcription factors, Irx3 and Irx5. Results provide insight into the molecular mechanisms underlying cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis.
Gaborit N, Sakuma R, Wylie JN, Kim KH et al. Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology. Development 2012 Nov;139(21):4007-19. PMID: 22992950
