B7x effect on CD8 T cell-mediated diabetes model AI4αβ: pancreatic CD8 T cells
Summary:
Analysis of pancreatic AI4αβ CD8 T cells isolated from Rip-B7xAI4αβ (overexpressing B7x in the β cells) and AI4αβ (lacking B7x) mice. B7x inhibits CD8 T cell-induced diabetes. Results provide insight into the molecular basis for abrogation of diabetes by B7x overexpression in β cells.
Lee JS, Scandiuzzi L, Ray A, Wei J et al. B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells. J Immunol 2012 Oct 15;189(8):4165-74. PMID: 22972920
