Chlamydia muridarum genital tract infection model: CD4 T cells
Summary:
Anaysis of Chlamydia-specific CD4 T cell clones that terminate Chlamydia replication in epithelial cells via an iNOS-dependent or iNOS-independent mechanism. Results provide insight into two independent and redundant T cell mechanisms for clearing C. muridarum genital tract infections.
Johnson RM, Kerr MS, Slaven JE. Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract. J Immunol 2012 Feb 15;188(4):1896-904. PMID: 22238459
Johnson RM, Brunham RC. Reply to Vicetti Miguel et al., "Setting Sights on Chlamydia Immunity's Central Paradigm: Can We Hit a Moving Target?" Infect Immun 2017 Jul;85(7). PMID: 28634196
