Analysis of CD4+CD25+ T-regulatory cells (Treg) from HDAC6-deficient C57BL6 mice. Foxp3+ Tregs are key to immune homeostasis and express multiple HDACs. Results provide insight into the role of the HDAC6 isoform in the suppressive functions of Foxp3+ Tregs.
de Zoeten EF, Wang L, Butler K, Beier UH et al. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol 2011 May;31(10):2066-78. PMID: 21444725