Leukemia inhibitory factor effect on Sin3a-silenced MCF7 breast cancer cell line
Summary:
Analysis of SIN3 transcription regulator homolog A (Sin3a)-depleted MCF7 cells stimulated with LIF cytokine to activate signal transducer and activator of transcription 3 (STAT3). STAT3 transcription factor is a potent oncogene. Results provide insight into role of Sin3a in mediating STAT3 activity.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Icardi L, Mori R, Gesellchen V, Eyckerman S et al. The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Proc Natl Acad Sci U S A 2012 Jul 24;109(30):12058-63. PMID: 22783022
