Analysis of LRRK2 (Gly2019Ser) mutant neural stem cells (NSC) treated with LRRK2 kinase specific inhibitor LRRK2-IN-1. The LRRK2 (G2019S) mutation causes familial Parkinson's disease. Results provide insight into molecular basis of progressive degeneration of NSCs caused by pathogenic LRRK2.
GPL571:
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Citation:
Liu GH, Qu J, Suzuki K, Nivet E et al. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature 2012 Nov 22;491(7425):603-7. PMID: 23075850