Interleukin-25-induced pulmonary inflammation model: Type 2 myeloid cells and other inflammatory subsets
Summary:
Analysis of inflammatory cell types from lungs of 4get females that received daily intra-tracheal injections of IL-25 for 4 days to induce antigen-independent type 2 inflammation. Results provide insight into role of IL-25 and its receptor in innate and adaptive pulmonary type 2 immune responses.
Petersen BC, Budelsky AL, Baptist AP, Schaller MA et al. Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology. Nat Med 2012 May;18(5):751-8. PMID: 22543263
