Tuberous sclerosis complex 1 deficient CD4 T cell response to T cell receptor stimulation
Summary:
Analysis of Tuberous sclerosis complex 1 (Tsc1) deficient CD4 T cells after T cell receptor stimulation using anti-CD3-CD28. Tsc1 is an mTOR signaling modulator involved in naive T cell quiescence and immune homeostasis regulation. Results provide insight into the role of Tsc1 in T cell quiescence.
Yang K, Neale G, Green DR, He W et al. The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat Immunol 2011 Jul 17;12(9):888-97. PMID: 21765414
