Runt homology domain expression effect on hematopoietic stem cells
Summary:
Analysis of c-Kit+Sca-1+Lin- hematopoietic stem cells (HSCs) lacking Runx1 or expressing the runt homology domain, RUNX1 (41-214). RUNX1(41-214) expression induces myelodysplastic syndrome (MDS) in mice. Results provide insight into molecular basis of MDS progression induced by RUNX1 (41-214).
Matsuura S, Komeno Y, Stevenson KE, Biggs JR et al. Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome. Blood 2012 Nov 8;120(19):4028-37. PMID: 22919028