MYC oncogene overexpression and silencing effect in medulloblastoma DAOY cells
Summary:
Analysis of medulloblastoma (MB)-derived cell lines genetically manipulated to either overexpress or silence the MYC oncogene. MYC overexpression and/or amplification is associated with poor clinical outcome. Results provide insight into transcriptional targets mediating the effects of MYC in MB.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Fiaschetti G, Castelletti D, Zoller S, Schramm A et al. Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma. Oncogene 2011 Jun 23;30(25):2823-35. PMID: 21317922
