DataSet Record GDS4477: Expression Profiles Data Analysis Tools Sample Subsets
Title: Pediatric glioblastoma brain tumors: histone H3.3 mutations
Cluster AnalysisGDS4477 Cluster Image
Summary: Analysis of pediatric glioblastoma (GBM) tumors with mutations in H3F3A gene. Mutation of key residues in histone H3.3 are specific to GBM and highly prevalent in children and young adults. Results indicate that defects in chromatin architecture underlie pediatric GBM pathogenesis.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
  • Schwartzentruber J, Korshunov A, Liu XY, Jones DT et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 2012 Jan 29;482(7384):226-31. PMID: 22286061
Reference Series: GSE34824 Sample count: 27
Value type: count Series published: 2012/03/01