Larval brains and imaginal discs with centrosome loss or amplification
Summary:
Analysis of 3rd instar larval brains and imaginal discs that lack centrosomes (DSas-4 and DSas-6) or have too many centrosomes (SakOE). Centrosome defects are common to many cancers. Results provide insight into the effects of centrosome loss or amplification on cell physiology.
Baumbach J, Levesque MP, Raff JW. Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila. Biol Open 2012 Oct 15;1(10):983-93. PMID: 23213376