Model for the manic pole of bipolar disorder: hippocampus
Summary:
Analysis of hippocampi from Madison (MSN) and hsd:ICR (ICR) adult males. The inbred MSN strain displays a naturally manic phenotype relative to the outbred ICR ancestral strain. Results provide insight into molecular mechanisms underlying the manic pole of bipolar disorder.
Saul MC, Gessay GM, Gammie SC. A new mouse model for mania shares genetic correlates with human bipolar disorder. PLoS One 2012;7(6):e38128. PMID: 22675514