Analysis of primary adrenocortical cells transduced with oncogenic Ras and a truncated form of p53. The acquisition order of the genetic alterations results in distinct adrenocortical tumor (ACT) phenotypes. Results provide insight into the molecular mechanisms underlying ACT pathogenesis.
Herbet M, Salomon A, Feige JJ, Thomas M. Acquisition order of Ras and p53 gene alterations defines distinct adrenocortical tumor phenotypes. PLoS Genet 2012;8(5):e1002700. PMID: 22589739
