Wfs1 deficiency model of Wolfram syndrome: hypothalamus
Summary:
Analysis of hypothalami from Wfs1-knockout, 129SV animals. Wfs1 deletion models Wolfram syndrome (WS), an autosomal recessive disorder characterized by multiple endocrine failure. Results provide insight into the molecular mechanisms underlying WS.
Kõks S, Soomets U, Plaas M, Terasmaa A et al. Hypothalamic gene expression profile indicates a reduction in G protein signaling in the Wfs1 mutant mice. Physiol Genomics 2011 Dec 16;43(24):1351-8. PMID: 22028430
