Analysis of macrophages from C57BL/6.MOLFc4(51Mb)-Ldlr-/- mice. This model harbors an atherosclerosis susceptibility locus and the region homologous to the human 9p21 locus associated with coronary artery disease. Results provide insight into the molecular basis of increased atherosclerotic risk.
Kuo CL, Murphy AJ, Sayers S, Li R et al. Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation. Arterioscler Thromb Vasc Biol 2011 Nov;31(11):2483-92. PMID: 21868699
