Chronic suppression of phosphodiesterase 10A effect on striatum and hippocampus
Summary:
Analysis of C57BL6 striatum and hippocampus following chronic inhibition of PDE10A activity by dosing with PDE10A inhibitor TP-10 or by PDE10A knockout. PDE10A transcripts are significantly downregulated in Huntington's disease (HD) brain. Results provide insight into the molecular basis of HD.
Kleiman RJ, Kimmel LH, Bove SE, Lanz TA et al. Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington's disease. J Pharmacol Exp Ther 2011 Jan;336(1):64-76. PMID: 20923867
