DataSet Record GDS4544: Expression Profiles Data Analysis Tools Sample Subsets
Title: G-protein-coupled receptor kinase 2 inhibition effect on HEK cells in vitro and in vivo
Cluster AnalysisGDS4544 Cluster Image
Summary: Analysis of HEK cells expressing dominant-negative GRK2-K220R. HEK cells were cultured, or expanded in NOD.Scid mice, or re-cultured after NOD.Scid expansion. GRK2-K220R enhances growth of NOD.Scid HEK cells but not cultured HEK cells. Results provide insight into basis of growth control by GRK2.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
  • Fu X, Koller S, Abd Alla J, Quitterer U. Inhibition of G-protein-coupled receptor kinase 2 (GRK2) triggers the growth-promoting mitogen-activated protein kinase (MAPK) pathway. J Biol Chem 2013 Mar 15;288(11):7738-7755. PMID: 23362259
Reference Series: GSE42771 Sample count: 12
Value type: count Series published: 2012/12/06