DataSet Record GDS4588: Expression Profiles Data Analysis Tools Sample Subsets
Title: APCΔ468 model of polyposis: regulatory T cells from various organs
Cluster AnalysisGDS4588 Cluster Image
Summary: Analysis of T-regulatory cells (Treg) from various organs (small intestine, spleen, mesenteric lymph node) of polyp-ridden Foxp3-GFPxAPCΔ468 reporter males. Tregs from the polyposis model promote cancer. Results provide insight into molecular mechanisms underlying these pathogenic Tregs.
Organism: Mus musculus
Platform: GPL6246: [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
  • Blatner NR, Mulcahy MF, Dennis KL, Scholtens D et al. Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer. Sci Transl Med 2012 Dec 12;4(164):164ra159. PMID: 23241743
  • Keerthivasan S, Aghajani K, Dose M, Molinero L et al. β-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells. Sci Transl Med 2014 Feb 26;6(225):225ra28. PMID: 24574339
Reference Series: GSE41229 Sample count: 44
Value type: count Series published: 2012/09/30