DataSet Record GDS4802: Expression Profiles Data Analysis Tools Sample Subsets
Title: WTX overexpression effect on kidney cell line
Cluster AnalysisGDS4802 Cluster Image
Summary: Analysis of HEK293 embryonic kidney cells overexpressing WTX, a tumor suppressor frequently inactivated in Wilms tumor. Ectopic expression of WTX in HEK293 cells activates p53 through lysine acetylation. Results provide insight into a role for WTX in the regulation of p53 activity.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
  • Kim WJ, Rivera MN, Coffman EJ, Haber DA. The WTX tumor suppressor enhances p53 acetylation by CBP/p300. Mol Cell 2012 Mar 9;45(5):587-97. PMID: 22285752
Reference Series: GSE34715 Sample count: 4
Value type: count Series published: 2012/01/01