Pan-peroxisome proliferator-activated receptor agonist effect on various tissues: dose response
Summary:
Analysis of liver, heart, kidney and skeletal muscle from animals treated with different doses (therapeutic, toxic) of PPM-201, a pan-peroxisome proliferator-activated receptor (pan-PPAR) agonist. Results provide insight into molecular bases of organ-specific toxicity induced by a panPPAR agonist.
Lee CM, Mudaliar MA, Haggart DR, Wolf CR et al. Simultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicology. PLoS One 2012;7(12):e48238. PMID: 23272042
