Analysis of lungs of C57BL/6J animals deficient for Gata5, a transcription factor expressed in the lung. Gata5 deficiency causes airway constrictor hyperresponsiveness (AHR). Results provide insight into the molecular mechanisms by which Gata5 deficiency leads to AHR.
Chen B, Moore TV, Li Z, Sperling AI et al. Gata5 deficiency causes airway constrictor hyperresponsiveness in mice. Am J Respir Cell Mol Biol 2014 Apr;50(4):787-95. PMID: 24199649