GPR120-deficient white adipose tissue response to a high fat diet
Summary:
Analysis of white adipose tissues (WAT) of GPR120 null mutants fed a high fat diet (HFD). GPR120-deficient animals on a HFD develop obesity, glucose intolerance and fatty liver. Results provide insight into the molecular basis of the metabolic changes in WAT of GPR120-deficient mice.
Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A et al. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 2012 Feb 19;483(7389):350-4. PMID: 22343897
