Analysis of primary lung cells FACS-isolated from Bmi1 deficient mutants. BMI1, a member of the Polycomb Repressive Complex 1, is required for the self-renewal of adult stem cells. Results provide insight into the mechanisms underlying the BMI1-dependent regulation of lung stem cell self-renewal.
Zacharek SJ, Fillmore CM, Lau AN, Gludish DW et al. Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci. Cell Stem Cell 2011 Sep 2;9(3):272-81. PMID: 21885022