C-C Chemokine receptor 5 deficient lungs with melanoma metastasis: time course
Summary:
Analysis of lungs from CCR5-deficient mutants 6 to 48 hrs after tail vein injection with B16-F10 melanoma cells. Lungs of CCR5-deficient mutants develop fewer metastatic nodules than in wild type animals. Results provide insight into the molecular mechanisms underlying CCR5-dependent metastasis.
Mango RL, Wu QP, West M, McCook EC et al. C-C chemokine receptor 5 on pulmonary mesenchymal cells promotes experimental metastasis via the induction of erythroid differentiation regulator 1. Mol Cancer Res 2014 Feb;12(2):274-82. PMID: 24197118
