Liver response to a metformin supplemented high fat diet deficient in methionine and choline
Summary:
Analysis of livers of animals fed a methionine- and choline- deficient, high fat diet (MCD+HF) containing metformin. MCD+HF models non-alcoholic steatohepatitis (NASH). Results provide insight into the feasibility of using metformin, an anti-diabetic drug, to treat NASH without underlying diabetes.
Kita Y, Takamura T, Misu H, Ota T et al. Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis. PLoS One 2012;7(9):e43056. PMID: 23028442
