DataSet Record GDS4893: Expression Profiles Data Analysis Tools Sample Subsets
Title: Heart response to isocitrate dehydrogenase 2 mutations IDH2R140Q and IDH2R172K
Cluster AnalysisGDS4893 Cluster Image
Summary: Analysis of hearts from transgenics with conditionally-activated isocitrate dehydrogenase 2 mutant (IDH2) R140Q and R172K alleles. Mutant IDH2 causes cardiomyopathy and neurodegeneration. Results provide insight into molecular mechanisms underlying the cardiac defects associated with IDH2 mutations.
Organism: Mus musculus
Platform: GPL6246: [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
  • Akbay EA, Moslehi J, Christensen CL, Saha S et al. D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Genes Dev 2014 Mar 1;28(5):479-90. PMID: 24589777
Reference Series: GSE54838 Sample count: 12
Value type: count Series published: 2014/03/01