DataSet Record GDS4903: Expression Profiles Data Analysis Tools Sample Subsets
Title: Rheumatoid arthritic synovium response to rituximab
Cluster AnalysisGDS4903 Cluster Image
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Summary: Analysis of synovial biopsy samples from anti-TNF resistant rheumatoid arthritis (RA) patients 12 wks after the start of rituximab (RTX) therapy. RTX is a mAb against CD20, expressed on subsets of B cells. Results provide insight into how RTX-induced B cell depletion interferes with RA pathogenesis.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citations:
  • Gutierrez-Roelens I, Galant C, Theate I, Lories RJ et al. Rituximab treatment induces the expression of genes involved in healing processes in the rheumatoid arthritis synovium. Arthritis Rheum 2011 May;63(5):1246-54. PMID: 21337318
  • Lauwerys BR, Hernández-Lobato D, Gramme P, Ducreux J et al. Heterogeneity of synovial molecular patterns in patients with arthritis. PLoS One 2015;10(4):e0122104. PMID: 25927832
Reference Series: GSE24742 Sample count: 24
Value type: count Series published: 2010/10/19