Glucose effect on young pancreatic islets: dose response and time course
Summary:
Analysis of islets isolated from young animals and cultured at 3mM glucose (G3) for 10 hr (T0) and then challenged with 11mM glucose for 1 hr (T1) and 4 hr (T4). Islets cultured at G3 for 2 days were also examined. Results provide insight into the kinetics of molecular response of islets to glucose.
Moreno-Asso A, Castaño C, Grilli A, Novials A et al. Glucose regulation of a cell cycle gene module is selectively lost in mouse pancreatic islets during ageing. Diabetologia 2013 Aug;56(8):1761-72. PMID: 23685457