Analysis of MCF-7 breast cancer cells treated with laccaic acid A (LCA). LCA, a highly substituted anthraquinone natural product, is a small molecule inhibitor of DNA methyltransferase 1 (Dnmt1). Results provide insight into the degree of selectiveness of LCA’s inhibitory activity on Dnmt1.
GPL6244:
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Citation:
Fagan RL, Cryderman DE, Kopelovich L, Wallrath LL et al. Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1. J Biol Chem 2013 Aug 16;288(33):23858-67. PMID: 23839987
