Secreted frizzled-related protein 5 mutation effect on gonadal white adipose tissue
Summary:
Analysis of gonadal white adipose tissues (WATs) of secreted frizzled-related protein 5 (Sfrp5) mutants. Sfrp5 expression increases during adipogenesis and in the WATs of obese mice. The Sfrp5 mutation is a premature stop codon at Gln7. Results provide insight into the role of Sfrp5 in WAT biology.
Mori H, Prestwich TC, Reid MA, Longo KA et al. Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition. J Clin Invest 2012 Jul;122(7):2405-16. PMID: 22728933
