Analysis of A375P melanoma cells depleted for PGC1alpha. PGC1alpha is a transcriptional coactivator that promotes mitochondrial biogenesis and respiration. A375P is a cell line that overexpresses PGC1alpha. Results provide insight into the role of PGC1alpha in melanoma.
GPL571:
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Citation:
Vazquez F, Lim JH, Chim H, Bhalla K et al. PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell 2013 Mar 18;23(3):287-301. PMID: 23416000
