Diabetes and Obesity Regulated gene gain-of-function effect on skeletal muscle
Summary:
Analysis of quadriceps from a muscle-specific, Diabetes and Obesity Regulated gene (DOR; also named Tp53inp2) overexpression line (SKM-Tg). DOR gain of function causes a reduction in muscle mass. Results provide insight into the functional role of DOR in skeletal muscle.
Sala D, Ivanova S, Plana N, Ribas V et al. Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes. J Clin Invest 2014 May;124(5):1914-27. PMID: 24713655
