DataSet Record GDS5068: Expression Profiles Data Analysis Tools Sample Subsets
Title: Rheumatoid arthritic synovium response to tocilizumab
Cluster AnalysisGDS5068 Cluster Image
Summary: Analysis of synovial biopsies from rheumatoid arthritis patients before and 12 weeks after the start of tocilizumab (TCZ) therapy. Results compared to those obtained from methotrexate (MTX) therapy (GDS5069) and provide insight into the differences in the mechanisms of action between TCZ and MTX.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
  • Ducreux J, Durez P, Galant C, Nzeusseu Toukap A et al. Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol 2014 Jan;66(1):15-23. PMID: 24449571
  • Lauwerys BR, Hernández-Lobato D, Gramme P, Ducreux J et al. Heterogeneity of synovial molecular patterns in patients with arthritis. PLoS One 2015;10(4):e0122104. PMID: 25927832
Reference Series: GSE45867 Sample count: 24
Value type: transformed count Series published: 2013/12/30