Analysis of non-proliferating myotubes infected with the Rocky Mountain Laboratory prion strain. Myotubes derived from the C2C12 myoblast cell line. Non-proliferating cells accumulate high levels of prions. Results provide insight into the cellular impact of prion infection.
Herbst A, Banser P, Velasquez CD, Mays CE et al. Infectious prions accumulate to high levels in non proliferative C2C12 myotubes. PLoS Pathog 2013;9(11):e1003755. PMID: 24244171