Small-molecule inhibition of BRDT effect on testis
Summary:
Analysis of testes from animals treated with JQ1, a small-molecule inhibitor of the testis-specific bromodomain-containing protein BRDT. BRDT is essential for spermatogenesis. Results provide insight into the molecular consequences of BRDT inhibition by JQ1.
Matzuk MM, McKeown MR, Filippakopoulos P, Li Q et al. Small-molecule inhibition of BRDT for male contraception. Cell 2012 Aug 17;150(4):673-84. PMID: 22901802
