Adaptor protein ASC deficiency effect on bone marrow dendritic cells
Summary:
Analysis of bone marrow dendritic cells of animals lacking ASC, an adaptor protein that contributes to innate immunity via the assembly of inflammasome complexes. Results provide insight into the inflammasome-independent role of ASC in regulating the antigen presenting function of dendritic cells.
Ippagunta SK, Malireddi RK, Shaw PJ, Neale GA et al. The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nat Immunol 2011 Sep 4;12(10):1010-6. PMID: 21892172
