isp-1;ced-4 double mutation effect on young adults
Summary:
Analysis of isp-1;ced-4 double mutants. ced-4 mutation in the intrinsic apoptosis signaling pathway suppresses the longevity of electron transport chain mutant isp-1. Results provide insight into molecular mechanisms underlying lifespan expansion.
GPL200:
[Celegans] Affymetrix C. elegans Genome Array
Citation:
Yee C, Yang W, Hekimi S. The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Cell 2014 May 8;157(4):897-909. PMID: 24813612
