Lung tumors arising from Wnt/beta-catenin signaling activation and constitutively active Kras mutant
Summary:
Analysis of lung tumors resulting from the concurrent activation of Wnt/beta-catenin signaling and expression of a constitutively active Kras mutant in the lung epithelium. 21% of lung tumors have Kras mutations. Results provide insight into the role of Wnt/beta-catenin signaling in lung cancer.
Pacheco-Pinedo EC, Durham AC, Stewart KM, Goss AM et al. Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium. J Clin Invest 2011 May;121(5):1935-45. PMID: 21490395
