CSN5 depletion effect on hepatocellular carcinoma cell lines
Summary:
Analysis of Huh7 and HepG2 hepatocellular carcinoma (HCC) cells depleted for CSN5, the fifth subunit of the COP9 signalosome. CSN5 expression is elevated in early HCC. Result provide insight into the role of CSN5 in the pathogenesis of HCC.
Lee YH, Judge AD, Seo D, Kitade M et al. Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response. Oncogene 2011 Oct 6;30(40):4175-84. PMID: 21499307
