DataSet Record GDS5242: Expression Profiles Data Analysis Tools Sample Subsets
Title: Interleukin-21 effect on STAT3-deficient naïve B cells from autosomal dominant hyper IgE syndrome patients
Cluster AnalysisGDS5242 Cluster Image
Summary: Analysis of naïve B cells purified from peripheral blood of AD-HIES patients with STAT3 loss-of-function mutation and then cultured with CD40 ligand alone or together with interleukin-21. Results provide insight into IL-21R/STAT3 signaling induced genes underlying naïve B cell differentiation.
Organism: Homo sapiens
Platform: GPL6244: [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
  • Berglund LJ, Avery DT, Ma CS, Moens L et al. IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts. Blood 2013 Dec 5;122(24):3940-50. PMID: 24159173
Reference Series: GSE51587 Sample count: 14
Value type: transformed count Series published: 2014/01/09