Interleukin 4, interleukin 13 and tumor necrosis factor-α effect on Matrigel-cultured IMR-90 lung fibroblast cells
Summary:
Analysis of IMR-90 cells cultured on Matrigel and treated with IL-4, IL-13 or TNFα. Type 2 inflammatory processes mediated by IL-4 and IL-13 are implicated in pathologic lung fibrogenesis. Results provide insight into molecular mechanisms underlying the onset and maintenance of pulmonary fibrosis.
GPL6480:
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)
Citation:
Chandriani S, DePianto DJ, N'Diaye EN, Abbas AR et al. Endogenously expressed IL-13Rα2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts. J Immunol 2014 Jul 1;193(1):111-9. PMID: 24879793
