DataSet Record GDS5266: Expression Profiles Data Analysis Tools Sample Subsets
Title: Cyclin-dependent kinase inhibitor R547 effect on peripheral blood mononuclear cells: dose response and time course
Cluster AnalysisGDS5266 Cluster Image
Summary: Analysis of peripheral blood mononuclear cells treated with CDK inhibitor R547 at 2 doses for 2 and 24 hours. R547 exerts an antiproliferative effect on various cell lines. Results compared with those from DU145 (GDS5267) and HCT116 cells (GDS5268) to identify pharmacodynamic biomarkers for R547.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
  • Berkofsky-Fessler W, Nguyen TQ, Delmar P, Molnos J et al. Preclinical biomarkers for a cyclin-dependent kinase inhibitor translate to candidate pharmacodynamic biomarkers in phase I patients. Mol Cancer Ther 2009 Sep;8(9):2517-25. PMID: 19755512
Reference Series: GSE15389 Sample count: 37
Value type: count Series published: 2009/03/26