Hydrogen peroxide-inducible clone-5 deficiency effect on dexamethasone-treated osteosarcoma cells: time course
Summary:
Analysis of U2OS-GR osteosarcoma cells (which stably express glucocorticoid receptor α) depleted for hydrogen peroxide-inducible clone-5 (Hic-5) then treated with the GR ligand dexamethasone for up to 24hrs. Results provide insight into the role of LIM domain coregulator Hic-5 in GR signaling.
Chodankar R, Wu DY, Schiller BJ, Yamamoto KR et al. Hic-5 is a transcription coregulator that acts before and/or after glucocorticoid receptor genome occupancy in a gene-selective manner. Proc Natl Acad Sci U S A 2014 Mar 18;111(11):4007-12. PMID: 24591583
