Analysis of alopecic skin from C3H/HeJ animals. The C3H/HeJ strain develops spontaneous alopecia areata (AA) with high similarity to human AA. AA is an autoimmune disease resulting from damage of hair follicle by T cells. Results provide insight into molecular mechanisms underlying AA pathogenesis.
Xing L, Dai Z, Jabbari A, Cerise JE et al. Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition. Nat Med 2014 Sep;20(9):1043-9. PMID: 25129481
