Analysis of H929 and U266 myeloma cells treated with the natural triterpenoid pristimerin. Multiple myeloma tumors exhibit dysregulated cyclin D expression. Pristimerin identified from a chemical library screen for compounds that induce suppression of transcription from the cyclin D2 promoter.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Tiedemann RE, Schmidt J, Keats JJ, Shi CX et al. Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo. Blood 2009 Apr 23;113(17):4027-37. PMID: 19096011
