DataSet Record GDS5279: Expression Profiles Data Analysis Tools Sample Subsets
Title: Pristimerin effect on myeloma cell lines
Cluster AnalysisGDS5279 Cluster Image
Summary: Analysis of H929 and U266 myeloma cells treated with the natural triterpenoid pristimerin. Multiple myeloma tumors exhibit dysregulated cyclin D expression. Pristimerin identified from a chemical library screen for compounds that induce suppression of transcription from the cyclin D2 promoter.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
  • Tiedemann RE, Schmidt J, Keats JJ, Shi CX et al. Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo. Blood 2009 Apr 23;113(17):4027-37. PMID: 19096011
Reference Series: GSE14011 Sample count: 4
Value type: count Series published: 2008/12/18