Hepatocyte nuclear factor 4 alpha deficiency effect on the colon
Summary:
Analysis of hepatocyte nuclear factor 4 alpha (HNF4-alpha) deficient colons of 1 year old animals. HNF4-alpha is a transcription factor. Deletion of HNF4-alpha confined to the epithelial colon. Results provide insight into the role of HNF4-alpha in maintaining intestinal inflammatory homeostasis.
Darsigny M, Babeu JP, Dupuis AA, Furth EE et al. Loss of hepatocyte-nuclear-factor-4alpha affects colonic ion transport and causes chronic inflammation resembling inflammatory bowel disease in mice. PLoS One 2009 Oct 29;4(10):e7609. PMID: 19898610
